We are regulars in the Charlotte to Orlando trip. Not quite as far as Detroit...
I share our normal plan, you might find some of it helpful...
When our kids were younger, for a long weekend trip, we will normally leave after work/school (say on Friday). We will drive to Jacksonville, and stay there overnight. The reason for that, the hotels there are generally cheaper than in Orlando, and we are only about 2 hours away when we wake up the next morning.
Comfortable places to stop: Buc-ee's Travel Center. There are a few, biggest and cleanest restrooms anywhere.
The 75/85 mixing bowl is Atlanta is horrible. As others have said, try to hit off-hours. Or, you may want to to try and take the I-77 to I-26 to I-95 to I-4 route. You would skip Atlanta, and I think it is not much further.
We are a Hilton Honors member, we try to plan our route with a stop that makes sense and is cheaper, For us, I try to get off the road between 10 PM and midnight if I was working that day. I also try to get on the road by 5 AM if it is a driving day. For us, 12 hours is really the limit of what we like to do in one day. We often travel from Charlotte to Disney, and up to NY (family). In both cases, we tend to make it a two day trip outgoing, and a one day trip on return. You sound like a seasoned traveler, one item I would recommend is we have a six port USB charger for our car. You may want two...
My only other comment, we have taken both the slow roll and the power drive. Both have their place. but if you have some planned out stopping points, it kinda gives you a goal. Just a mental trick, but it may help...
Some money saving tips:
If you can get discounted gift cards, do that (Our local supermarket does $10 gas cards every once in a while). Same type of thing with restaurants, if you are into that.
Good luck. Yes, driving is longer, but so much easier to bring what you need, have a car when you get there, etc...