I'm not quite 1000 miles, 972 from my house in central Arkansas to bay lake tower if I go through Atlanta(which I don't), 944 if I don't and go through Dothan Alabama.
I thought I would post some of our experiences. My wife and I regularly...4-6 times a year do 400-600 mile road trips, and we have gone to Florida 4 times to Disney(I think), and 3 or 4 times to other areas in Florida.
I always do all the driving and navigating. She is in charge of snacks, any any questions I can't answer with google maps. I have seen others use wayze, I have gone back and forth, and I personally prefer google maps. Any GPS app can sometimes get confused(including dedicated GPS remember those when it wasn't in your phone? I feel old) But I am just most familiar with how it works, and how to search for things along the route such as rest stops, I also like the gas prices and how they show up in the app.
Our route to Disney is leave Central Arkansas, go to Memphis, then I-22 out of Memphis through Birmingham and then route 231 to Dothan Alabama. After Dothan continue on 231 until you reach I10, then its I10 to 75, then the turnpike, and we have found going the back way into Disney works best because we avoid I4. It is not interstate the whole way especially south of Birmingham, but it is very easy drive, 4 lane road for 95% of the way, just 2 lane for a very short period of time. I won't say its a pretty drive at all, but it is a nice easy drive.
When we drive to Disney we stop in Dothan Alabama. That is about 9 hours for us, which puts us in Disney the following day around lunch time. I have done the drive in one day to Florida and I'm always toast the next day, so for us to be ready to hit the ground running we split the drive up. The reason for Dothan is because the next good area to stop is another 2 hours down the road after Dothan which is a little too far for us. I usually book a hotel on the way down, but don't have one on the way home. I have done the drive home in one day, we have also stopped, it just depends on when we get on the road, and how tired I am.