We've made that trip numerous times. We're about an hour NW of Philly. What works for us (because our kids have always been great travelers) is to leave around 5:00 a.m. We drive to Savannah, GA (the Port Wentworth exit) and spend the night there. We stop several times along the way for lunch (usually just get pizza delivered to the room for dinner), gas, and bathroom breaks. We usually make it to Savannah by about 7:00 depending on how many stops we've made along the way and how long we lingered at lunch. We can get a good night's sleep and be up and ready to hit the road by 8:00 the next morning. It's about a 4 hour drive to Orlando from there (including a stop at the Florida Welcome Center for orange juice and Disney brochures).