Definitely make AND KEEP them for hot restaurants and character meals you really want. Then, I would have in my head a loose schedule for other meals and make a few ps for those as well, which you can cancel or skip as needed (I know some disagree with me here, but skipping a ps isn't a big deal like skipping a true ressie-- Disney's system is set-up for no-shows.) On our recent trip we had a few things we were going to do no matter what-- 'Ohana dinner and breakfast, California Grill, Boma-- all popular meals that we didn't want to miss. I also had a number of ps set up for dinners on the other nights so I would have something available if I needed it-- I knew we would be in Epcot on Thursday, so I reserved LeCellier, knew we'd be in MK on Tuesday so I reserved a dinner at a monorail resort. I ended up cancelling most of these as we ended up not being in the right place at the right time, and we ended up going to a number of places with either walk-in or waits of 10 minutes or less: Kona Cafe, Spoodles, Wolfgang Pucks (actually there was quite a long wait here but we were able to sit at bar with no wait.) Anyway, I would make some PS so you have plenty of options, but don't be afraid to be spontaneous and try doing walk-in when the need arises.
At certain times of year, walk-in can be a lost cause-- it was fine for us late September but not so great when we went President's Week. Mid-November shouldn't be too bad, but you never know.