If you are looking for Tourism, then 192 is the kitschy area. It's actually not in Orlando, it's Kissimmee. International Drive can be a bit more dense and difficult to navigate, but I think it is a lot cleaner and more modern.
Orlando is not a one road town, though, and Disney is really not in the city anyways. Dr. Phillips (Sand Lake Road) is restaurant row, with more upscale smaller chains. The real upscale neighborhoods lie further north, however. Downtown and Thorton Park have some good independent dining, though not touristy attractions. If you want the more town feel, head up to Winter Park, which is a bit ritzy but nicely walkable.
If you do actually venture out of the park and explore, particularly getting away from I Drive and 192, that Orlando is a pretty diverse and nice city