I'm not sure about different branding, but the Scopalamine patch does require a prescription. It was amazingly helpful for me. Bonine really didn't help me all the much, but with the patch, I had no problems whatsoever. With the patch, you put it on 24 hours in advance of your trip and you can wear it for up to 72 hours. That all being said, I will say that there are side effects, including dry mouth and blurred vision for some (it dilates your eyes a bit--the blurred vision for me was only for close up, nothing else). Also, some people have a rebound when taking it off--specifically some nausea or GI issues. This is more typical if you wear it for a longer period of time. For me, it was worth it, b/c it made my trip so much more enjoyable!